李家洋科研成就科研综述李家洋利用模式植物探索植物内源激素与外界环境因子对高等植物生长发育的调控作用及其分子机理

（1）阐明了拟南芥植物生长素（吲哚乙酸，IAA）合成的直接前体物质主要来自色氨酸合成途径的中间产物：吲哚-3-甘油磷酸（IGP）

（2）系统鉴定和研究油菜素内酯的应答基因，发现油菜素内酯可通过通过诱导细胞周期蛋白基因的表达而促进细胞分裂，可在拟南芥细胞培养中替代细胞分裂素提出植物细胞内可能存在一条新的油菜素内酯信号转导途径的假说

（3）发展系统鉴定植物功能基因的植物表达文库转化法，分离了一批株型与育性等生长发育性状发生改变的拟南芥突变体，并克隆出相关基因 

2019年11月20日，中国农业科学院发布了10项能够充分代表2018年我国农业科技前沿研究水平、取得重大突破性进展的基础科学研究成果，其中包括：水稻理想株型基因提高产量与稻瘟病抗性

该研究由中国科学院遗传与发育生物学研究所李家洋院士团队和四川农业大学水稻研究所陈学伟团队主导，揭示了水稻理想株型主效基因既能提高水稻产量、又能增强对稻瘟病抗性的调控新机制，打破了单个基因不可能同时实现增产和抗病的传统观点，为高产高抗育种提供了重要理论基础和实际应用新途径

 2021年7月19日，双季早粳水稻新品种“中科发早粳1号”测产现场会在江西省上高县举行

200亩的示范田里，金色稻浪翻滚，在机插秧、人工插秧、直播和抛秧四种栽培模式下，“中科发早粳1号”均表现优异，不仅产量创出新高，而且在苗期抗冷、抗旱，成熟期抗穗发芽等农艺性状中表现突出

“这一新品种实现了我国双季早粳稻‘零的突破’，填补了双季早粳品种在我国水稻生产中的空白，这意味着，今后我们可以提前一个季度吃上好吃的新粳米了

”中国科学院院士、中国科学院遗传与发育生物学研究所研究员李家洋满怀喜悦

 中科院李家洋院士团队创制世界首例重新设计与快速驯化的四倍体水稻材料，2021年初，这一成果发表在科学期刊《细胞》上，被业界认为有望开辟一条野生植物驯化新路

 2022年4月，中科院遗传与发育生物学研究所李家洋团队的最新研究揭示了水稻穗重和穗数之间相互制约的分子机制，从而为打破这种制约关系提供了一种可行方法，为突破水稻产量瓶颈提供了新的遗传资源与研究思路

在此项最新研究中，团队创制出大量IPA1顺式调控区平铺删除的基因材料，并从中发掘出了可以同时提高穗重和穗数的材料IPA1-Pro10，该材料还同时具有株高变高、茎秆和根系粗壮的表型

经田间小区测产鉴定，IPA1-Pro10与对照品种中花11相比能够增产15.9%

该研究还进一步阐明了IPA1顺式调控区调控穗部表型的分子机制

 2022年，李家洋院士团队在山东省东营市黄河三角洲盐碱地农业试验站开展盐碱地科研工作

 学术论著Selected Peer-Reviewed ArticlesLi J, Ou-Lee T M, Raba R, et al. Arabidopsis Flavonoid Mutants Are Hypersensitive to UV-B Irradiation[J]. The Plant Cell, 1993, 5(2):171-179.Li J, Zhao J, Rose A B, et al. Arabidopsis Phosphoribosylanthranilate Isomerase: Molecular Genetic Analysis of Triplicate Tryptophan Pathway Genes[J]. The Plant Cell, 1995, 7(4):447-461.Li, J. The Arabidopsis thaliana trp5 mutant has a feedback-resistant anthranilate synthase and elevated soluble tryptophan[J]. PLANT PHYSIOLOGY, 1996, 110(1):51-59.Feng Q, Zhang Y, Hao P, Li J, et al. Sequence and analysis of rice chromosome 4[J]. Nature, 2002, 420(6913):316-320.Li X, Qian Q, Fu Z, Li J, et al. Control of tillering in rice[J]. Nature, 2003, 422(6932):618-621.Tian Z, Qian Q, Liu Q, Li J, et al. Allelic diversities in rice starch biosynthesis lead to a diverse array of rice eating and cooking qualities[J]. Proc Natl Acad Sci USA, 2009, 106(51):21760-21765.Huang X, Qian Q, Liu Z, Li J, et al. Natural variation at the DEP1 locus enhances grain yield in rice[J]. NATURE GENETICS, 2009, 41(4):494-497.Huang X, Kurata N,Li J, et al.A map of rice genome variation reveals the origin of cultivated rice[J]. Nature, 2012, 490(7421):497-501.Jiang L, Liu X, Li J, et al. DWARF 53 acts as a repressor of strigolactone signalling in rice[J]. Nature, 2013, 504(7480):401-405.Selected Invited ArticlesWang B and Li J (2019) Understanding the molecular bases of agronomic trait improvement in rice. Plant Cell. 31: 1416-1417.Bai, S, Yu, H, Wang, B, and Li, J (2018). Retrospective and perspective of rice breeding in China. J Genet Genomics 45: 603-612.Wang B, Smith SM and Li J (2018) Genetic Regulation of Shoot Architecture. Annu Rev Plant Biol 69: 437-468.Li J (2016) Rice breeding: never off the table. Natl Sci Rev 3, 275.Qian Q, Guo L, Smith SM, and Li J. (2016) Breeding high-yield superior-quality hybrid super-rice by rational design. Natl Sci Rev 3, 283-294.Xiong G, Li J, and Smith SM. (2016) Evolution of strigolactone perception by seeds of parasitic plants – reinventing the wheel. Mol Plant 9, 493-495.Smith S, and Li J (2014). Signalling and responses to strigolactones and karrikins. Curr Opin Plant Biol 21C, 23-29.Zuo J, and Li J (2014). Molecular genetic dissection of quantitative trait loci regulating rice grain size. Annu Rev Genet 48, 99-118.Zuo J and Li J (2013) Molecular Dissection of Complex Agronomic Traits of Rice: A Team Effort by Chinese Scientists in Recent Years. National Sci Rev.Li J and Chua N-H (2011) A comprehensive understanding of plant growth and development. Curr Opin Plant Biol 14:1-3.Wang Y and Li J (2011) Branching in rice. Curr Opin Plant Biol 14: 94-99.Wang Y and Li J (2008). Rice, rising. Nat Genet 40, 1273-1275.Wang Y and Li J (2008). Molecular basis of plant architecture. Annu Rev Plant Biol 59: 253-279.Han B, Xue Y, Li J, Deng X, and Zhang Q (2007) Rice functional genomics research in China. Phil Trans R Soc B 362: 1009–102.Wang Y and Li J (2006) Genes controlling plant architecture. Curr Opin Biotech 17: 123-129.Wang Y, Xue Y and Li J (2005) Towards molecular breeding and improvement of rice in China. Trends Plant Sci 10: 610-614.Selected Invited Book ChaptersLi J, Meng X, Li J, and Gao C (2019). Gene replacement by intron targeting with CRISPR-Cas9. Methods Mol Biol 1917, pp. 285-296.Bai S, Smith SM, and Li J (2018). Rice Plant Architecture: Molecular Basis and Application in Breeding. In: Rice Genomics, Genetics and Breeding (Sasaki T, Ashikari M), Springer Singapore, pp. 129-154.Li J, Li C, and Smith SM, eds (2017). Hormone Metabolism and Signaling in Plants. London, United Kingdom: ELSEVIER Academic Press. ISBN 978-0-12-811562-6.Smith SM, Li C, Li J (2017). Hormone function in plants. In: Hormone Metabolism and Signaling in Plants (Li J, Li C, Smith SM), Academic Press Elsevier (London UK), pp, 1-38.Wang B, Wang Y, Li J (2017). Strigolactones. In: Hormone Metabolism and Signaling in Plants (Li J, Li C, Smith SM) Academic Press Elsevier (London UK), pp. 327-359.Jiang Z, Li J, Qu L (2017). Auxins. In: Hormone Metabolism and Signaling in Plants (Li J, Li C, Smith SM) Academic Press Elsevier (London UK), pp. 39-76.Xiong G, Wang Y, Li J (2014) Action of strigolactones in plant. In The Enzymes. Vol 35 Signaling Pathways in Plants. (Machida Y, Lin C, Tamanoi F, Eds), Elsevier, pp. 57-84.Sang T and Li J (2013) Molecular genetic basis of the domestication syndrome in cereals. In Cereal Genomics-II (Gupta PK, Varshney RK, eds), Springer Science pp. 319-340.Yu Y, Wing RA and Li J (2013) Understanding genetic molecular basis of rice grain quality. In Genetics and Genomics of Rice(Zhang Q and Wing RA, eds), Springer New York Heidelberg Dordrecht London, pp. 237-254.Wang Y and Li J (2012) Regulation of plant architecture. In Plant Physiology and Molecular Biology (Chen X, Xue H, eds), Higher Education Press, Beijing, pp. 418-432.Wang Y, Chen M and Li J (2007) Rice. In Biotechnology in Agriculture and Forestry Vol. 59 Transgenic Crops IV (E.C. Pua and M.R.Davey, eds), Springer-Verlag Berlin Heidelberg, pp. 35-54. 授权专利根据2019年10月，中国科学院遗传与发育生物学研究所网站显示，李家洋作为第一发明人的中国国内外专利如下 ：专利号专利名称Philippines 1-2012501831Protein IPA1 related to plant architecture, its coding genes and usesUS 9,309,527 B2Protein IPA1 related to plant architecture, its coding genes and usesZL201010146613.8与植物株型相关的蛋白IPA1及其编码基因与应用ZL201010231207.1水稻稻米胶稠度调控基因分子标记及其应用ZL201010231209.0水稻稻米直链淀粉含量调控基因分子标记及其应用ZL201010231187.8水稻稻米糊化温度调控基因分子标记及其应用ZL200910083935.X一种水稻分蘖相关蛋白及其编码基因与应用ZL200910077629.5水稻茎秆机械强度控制基因BC10及其应用ZL200510088978.9水稻胚乳直链淀粉含量控制基因DU1及其应用ZL200510006770.8水稻胚乳甜质控制基因SU1及其应用ZL200410096425.3水稻籼粳分类控制基因PHR1及其应用ZL03132810.5水稻稻米糊化温度主效控制基因ALK及其应用ZL02144344.0拟南芥BUD1基因及其应用ZL02129196.9水稻分蘖控制基因MOC1及其应用ZL02131417.9水稻脆秆控制基因BC1及其应用科研成果奖励时间项目名称奖励名称获奖人员2003年我国科学家提示水稻高产的分子奥秘和超级杂交稻研究取得重大突破中国和世界十大科技进展 2005年高等植物株型形成的分子基础国家自然科学奖二等奖 李家洋、钱前、王永红、付志明、刘新仿 2010年水稻基因育种技术获突破性进展中国和世界十大科技进展 2017年水稻分子遗传学团队（李家洋领导）求是科技基金会杰出科技成就集体奖 2017年水稻高产优质性状形成的分子机理及品种设计国家自然科学奖一等奖 李家洋，韩斌，钱前，王永红，黄学辉 

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