曹晓风科研成就科研综述曹晓风在组蛋白甲基化研究方面，发现植物中首个H3K27去甲基化酶REF6，并提出REF6与LHP1共进化的理论；揭示组蛋白甲基化酶和去甲基化酶调控基因表达和维持转座子活性的分子机制，首次在基因组水平上证实转座子具有调控功能；系统研究了拟南芥中蛋白质精氨酸甲基转移酶的活性和调控开花的遗传学途径，发现AtPRMT5和AtPRMT3基因突变分别导致全基因组mRNA前体剪切和rRNA加工异常，揭示了蛋白质精氨酸甲基化通过转录后水平调控基因表达的新机理

在水稻小RNA研究方面，鉴定了水稻小RNA产生的关键因子及遗传途径；揭示不同小RNA对水稻重要农艺性状的影响  

2022年，曹晓风院士团队在山东省东营市黄河三角洲盐碱地农业试验站开展盐碱地科研工作 

学术论著截至2018年4月，曹晓风以第一作者和通讯作者在Science, Nature Genetics, Nature Communications, Annu Rev. Plant Biol, Current Biology, PNAS, Plant Cell 上发表多篇文章 

Xian Deng, Qi Qiu, Kaixuan He and Xiaofeng Cao*. The seekers: how epigenetic modifying enzymes find their hidden genomic targets in Arabidopsis. Current Opinion in Plant Biology. 45:75–81 (2018)Xuan Ma and Xiaofeng Cao*. Cotton variant genomes — a breakthrough in population genetics analysis. SCIENCE CHINA Life Sciences. (2018)Jianguo Wu, Rongxin Yang, Zhirui Yang, Shengze Yao, Shanshan Zhao, Yu Wang, Pingchuan Li, Xianwei Song, Lian Jin, Tong Zhou, Ying Lan, Lianhui Xie, Xueping Zhou, Chengcai Chu, Yijun Qi, Xiaofeng Cao*, and Yi Li*. ROS Accumulation and Antiviral Defence Control by microRNA528 in Rice. Nature Plant. 3: 16203 (2017)Xianwei Song and Xiaofeng Cao*. Transposon-mediated epigenetic regulation contributes to phenotypic diversity and environmental adaptation in rice. Current Opinion in Plant Biology. 36: 111-118 (2017)Xian Deng and Xiaofeng Cao*. Roles of pre-mRNA splicing and polyadenylation in plant development. Current Opinion in Plant Biology. 35: 45-53 (2017)Xia Cui, Falong Lu, Qi Qiu, Bing Zhou, Lianfeng Gu, Shuaibin Zhang, Yanyuan Kang, Xiekui Cui, Xuan Ma, Qingqing Yao, Jinbiao Ma, Xiaoyu Zhang, and Xiaofeng Cao*. REF6 recognizes a specific DNA sequence to demethylate H3K27me3 and regulate organ boundary formation in Arabidopsis. Nature Genetics. 48(6):694-699 (2016)Xian Deng, Tiancong Lu, Lulu Wang, Lianfeng Gu, Jing Sun, Xiangfeng Kong, Chunyan Liu*, and Xiaofeng Cao*. Recruitment of the NineTeen Complex to the activated spliceosome requires AtPRMT5. Proc. Natl. Acad. Sci. USA.113(19): 5447–5452 (2016)Xian Deng, Xianwei Song, Liya Wei, Chunyan Liu, and Xiaofeng Cao*. Epigenetic Regulation and the Epigenomic Landscape in Rice. National Science Review. 3(3): 309-327 (2016)Liya Wei, Lianfeng Gu, Xianwei Song, Xiekui Cui, Zhike Lu, Ming Zhou, Lulu Wang, Fengyi Hu, Jixian Zhai, Blake C. Meyers, and Xiaofeng Cao*. Dicer-like 3 produces transposable element-associated 24-nt siRNAs that control agricultural traits in rice. Proc. Natl. Acad. Sci. USA, 111 (10): 3877-3882 (2014).Runlai Hang, Chunyan Liu, Ayaz Ahmad, Yong Zhang, Falong Lu, and Xiaofeng Cao*. Arabidopsis Protein Arginine Methyltransferase 3 regulates ribosome biogenesis by affecting precursor ribosomal RNA processing. Proc. Natl. Acad. Sci. USA, 111 (45): 16190-16195 (2014)Hai Zhou, Ming Zhou, Yuanzhu Yang, Jing Li, Liya Zhu, Dagang Jiang, Jingfang Dong, Qinjian Liu, Lianfeng Gu, Lingyan Zhou, Mingji Feng, Peng Qin, Xiaochun Hu, Chengli Song, Jinfeng Shi, Xianwei Song, Erdong Ni, Xiaojin Wu, Qiyun Deng, Zhenlan Liu, Mingsheng Chen, Yao-Guang Liu, Xiaofeng Cao*, and Chuxiong Zhuang*. RNase ZS1 processes UbL40 mRNAs and controls thermo-sensitive genic male sterility in rice. Nature Communications (2014)Pedro Crevillén, Hongchun Yang, Xia Cui, Michael Greeff, Martin Trick, Qi Qiu, Xiaofeng Cao, and Caroline Dean. Epigenetic reprogramming that prevents transgenerational inheritance of the vernalized state. Nature, 515: 587-590 (2014)Xiekui Cui, Ping Jin, Xia Cui, Lianfeng Gu, Zhike Lu, Yongming Xue, Liya Wei, Jianfei Qi, Xianwei Song, Ming Luo, Gynheung An, and Xiaofeng Cao*. Control of transposon activity by a histone H3K4 demethylase in rice. Proc. Natl. Acad. Sci. USA, 110: 1953-1958 (2013).Falong Lu, Xia Cui, Shuaibin Zhang, Thomas Jenuwein, and Xiaofeng Cao*. Arabidopsis REF6 is a Histone H3 Lysine 27 Demethylase. Nature Genetics, 43:715-719 (2011).Xian Deng, Lianfeng Gu, Chunyan Liu, Tiancong Lu, Falong Lu, Zhike Lu, Peng Cui, Yanxi Pei, Baichen Wang, Songnian Hu, and Xiaofeng Cao*. Arginine methylation mediated by the Arabidopsis homolog of PRMT5 is essential for proper pre-mRNA splicing. Proc. Natl. Acad. Sci. USA, 107:19114-19119 (2010).Tetsu Kinoshita, Asuka Miura, Yeonhee choi, Yuki Kinoshita, Xiaofeng Cao, Steven E. Jacobsen, Robert L. Fischer, and Tetsuji Kakutani. One-way control of FWA imprinting in Arabidopsis endosperm by DNA methylation. Science, 303: 521-523 (2004).Daniel Zilberman, Xiaofeng Cao and Steven E. Jacobsen. ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation. Science, 299: 716-719 (2003).Xiaofeng Cao and Steven E. Jacobsen. Role of the Arabidopsis DRM methyltransferases in de novo DNA methylation and gene silencing. Current Biology, 12: 1138-1144 (2002a).Xiaofeng Cao and Steven E. Jacobsen. Locus specific control of asymmetric and CpNpG methylation by the DRM and CMT3 methyltransferase genes. Proc. Natl. Acad. Sci., USA, 99: 16491-16498 (2002b).Anders Lindroth#, Xiaofeng Cao#, James P. Jackson#, Daniel Zilberman, Claire M. McCallum, Steven Henikoff and Steven E. Jacobsen. Requirement of Chromomethylase3 for maintenance of CpXpG methylation. Science, 292: 2077-2080 (2001). (#These authors contributed equally to this work) .Xiaofeng Cao, Nathan M. Springer, Michael G. Muszynski, Ronald L. Phillips, Shawn Kaeppler, and Steven E. Jacobsen. Conserved plant genes with similarity to mammalian de novo DNA methyltransferases. Proc. Natl. Acad. Sci. USA, 97: 4979-4984 (2000).Xiaofeng Cao, Sally W. Rogers, Juliet Butler, Leonard Beevers, and John C. Rogers. Structural requirements for ligand binding by a probable plant vacuolar sorting receptor. The Plant Cell, 12: 493-506 (2000).Xiaofeng Cao, Paul Linstead, Fred Berger, Joe Kieber, and Liam Dolan. Differential ethylene sensitivity of epidermal cells is involved in the establishment of cell pattern in the Arabidopsis root. Physiologia Plantarum, 106: 311-317 (1999).Xiaofeng Cao, Zhibin Lu, Yuxian Zhu, Naisui Pan, and Zhangliang Chen. Cloning and sequencing of a tomato cDNA of ethylene-forming enzyme. Chinese Science Bulletin, 39: 430-434 (1994).Xiaofeng Cao, Rongchen Wang, Lungfei Yen, Zhibin Lu, Naisui Pan, and Zhangliang Chen. Construction of a pea tendril cDNA library and sequence analysis of a pea actin cDNA, PEAc1. Chinese Science Bulletin, 39: 332-337(1994).承担项目截至2017年11月，曹晓风先后担任科技部、农业部、国家自然科学基金委员会、中国科学院各类重大任务首席科学家，累计主持重大项目18项 

项目时间项目名称备注2009-01--2013-12植物重要器官形成的遗传和表观遗传调控机理研究主持，国家级2013-01--2017-12拟南芥AGO蛋白与mRNA互做网络的解析及miRNA调控蛋白翻译抑制的分子机理研究主持，国家级2013-08--2018-07水稻耐逆境胁迫的分子模块解析主持，部委级2014-01--2018-12拟南芥蛋白质精氨酸甲基化修饰的功能解析主持，国家级2016-01--2019-12核糖体RNA的加工和修饰调控植物生长发育的分子机理研究,主持，国家级2016-01--2020-12基因表达调控技术研究主持，国家级2016-07--2020-12水稻功能基因组研究与应用参与，国家级2017-06--2022-12水稻抗低温冷害的遗传及表观遗传调控网络研究主持，部委级参考资料来源： 科研成果奖励2020年1月10日，曹晓风参与“组蛋白甲基化和小RNA调控植物生长发育和转座子活性的机制研究”的项目获得2019年度国家自然科学奖二等奖 

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