美国艺术与科学院院士创院院士1780年5月4日，美国艺术与科学院由马萨诸塞州立法机构批准成立

根据其宪章记载，该院宗旨为“弘扬学术，以增进自由、独立、良善之公民德行”

首任院长为美国第一任副总统及第二任总统约翰·亚当斯，62位创始院士分别在政治、专业、商业等各领域拥有广泛的兴趣以及崇高的地位

 美国艺术与科学院的创院院士包括：Samuel Adams, John Adams, John Bacon, James Bowdoin, Charles Chauncy, John Clark, David Cobb, Samuel Cooper, Thomas Cushing, Nathan Cushing, William Cushing (威廉·库欣), Tristram Dalton, Francis Dana, Samuel Deane, Perez Fobes, Caleb Gannett, Henry Gardner, Benjamin Guild, John Hancock, Joseph Hawley, Edward Augustus Holyoke, Ebenezer Hunt, Jonathan Jackson, Charles Jarvis, Samuel Langdon, Levi Lincoln, Daniel Little, Elijah Lothrup, John Lowell, Samuel Mather, Samuel Moody, Andrew Oliver, Joseph Orne, Theodore Parsons, George Partridge, Robert Treat Paine (罗伯特·特里特·佩因), Phillips Payson, Samuel Phillips, Jr., John Pickering, Oliver Prescott, Zedekiah Sanger, Nathaniel Peaslee Sargeant, Micajah Sawyer, Theodore Sedgwick, William Sever, Stephen Sewall, David Sewall, John Sprague, Ebenezer Storer, Caleb Strong, James Sullivan, John Bernard Sweat, Nathaniel Tracy, Cotton Tufts, James Warren, Samuel West, Edward Wigglesworth, Joseph Willard, Samuel Williams, Abraham Williams, Nehemiah Williams, and James Winthrop.

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