裴钢科研成就科研综述裴钢利用G蛋白偶联受体变异验证了受体激活平衡态的假说

发现阿片受体（G蛋白偶联）C末端在激动剂作用下发生的磷酸化而导致阿片受体脱敏

揭示阿片受体信号脱敏和负反馈调节在阿片成瘾性形成中的重要作用

证明兴奋性氨基酸受体与阿片受体信号转导途径间存在crosstalk

发现氧化低密度脂蛋白可经过G蛋白途径激活p38MAPK而抑制平滑肌细胞的生长

发现中药有效成分天花粉蛋白能与HIV共受体（趋化因子受体）结合、增强受体的激活从而发挥抗HIV作用

揭示五次跨膜的趋化因子受体具有正常七次跨膜G蛋白偶联受体的功能 

学术论著截至2018年10月，裴钢在国际学术刊物发表研究论文100多篇，代表论文如下 ：Li, J., Wei, B., Guo, A., Liu, C., Huang, S., Du, F., ... & Pei, G. (2013). Deficiency of β-arrestin1 ameliorates collagen-induced arthritis with impaired TH17 cell differentiation [J]. Proceedings of the National Academy of Sciences, 110(18), 7395-7400.Liu, X., Zhao, X., Zeng, X., Bossers, K., Swaab, D. F., Zhao, J., & Pei, G. (2013). β-arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology[J]. Cell research, 23(3), 351.Chen, T., Shen, L., Yu, J., Wan, H., Guo, A., Chen, J., ... & Pei, G. (2011). Rapamycin and other longevity‐promoting compounds enhance the generation of mouse induced pluripotent stem cells[J]. Aging cell, 10(5), 908-911.Zhuang, L. N., Hu, W. X., Zhang, M. L., Xin, S. M., Jia, W. P., Zhao, J., & Pei, G. (2011). β-Arrestin-1 protein represses diet-induced obesity[J]. Journal of Biological Chemistry, 286(32), 28396-28402.Chen, T., Yuan, D., Wei, B., Jiang, J., Kang, J., Ling, K., ... & Pei, G. (2010). E‐Cadherin‐Mediated Cell–Cell Contact Is Critical for Induced Pluripotent Stem Cell Generation[J]. Stem cells, 28(8), 1315-1325.Yue, R., Kang, J., Zhao, C., Hu, W., Tang, Y., Liu, X., & Pei, G. (2009). β-Arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression[J]. Cell, 139(3), 535-546.Du, C., Liu, C., Kang, J., Zhao, G., Ye, Z., Huang, S., ... & Pei, G. (2009). MicroRNA miR-326 regulates T H-17 differentiation and is associated with the pathogenesis of multiple sclerosis[J]. Nature immunology, 10(12), 1252.Luan, B., Zhao, J., Wu, H., Duan, B., Shu, G., Wang, X., ... & Pei, G. (2009). Deficiency of a β-arrestin-2 signal complex contributes to insulin resistance[J]. Nature, 457(7233), 1146.Zou, L., Yang, R., Chai, J., & Pei, G. (2008). Rapid xenograft tumor progression in beta-arrestin1 transgenic mice due to enhanced tumor angiogenesis[J]. The FASEB Journal, 22(2), 355-364.Wang, Y., Tang, Y., Teng, L., Wu, Y., Zhao, X., & Pei, G. (2006). Association of β-arrestin and TRAF6 negatively regulates Toll-like receptor–interleukin 1 receptor signaling[J]. Nature immunology, 7(2), 139.Gao, H., Sun, Y., Wu, Y., Luan, B., Wang, Y., Qu, B., & Pei, G. (2004). Identification of β-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-κB pathways[J]. Molecular cell, 14(3), 303-317.Xu, N. J., Bao, L., Fan, H. P., Bao, G. B., Pu, L., Lu, Y. J., ... & Pei, G. (2003). Morphine withdrawal increases glutamate uptake and surface expression of glutamate transporter GLT1 at hippocampal synapses[J]. Journal of Neuroscience, 23(11), 4775-4784.Pu, L., Bao, G. B., Xu, N. J., Ma, L., & Pei, G. (2002). Hippocampal long-term potentiation is reduced by chronic opiate treatment and can be restored by re-exposure to opiates[J]. Journal of Neuroscience, 22(5), 1914-1921.Sun, Y., Cheng, Z., Ma, L., & Pei, G. (2002). β-Arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activation[J]. Journal of Biological Chemistry, 277(51), 49212-49219.Cheng, Z. J., Zhao, J., Sun, Y., Hu, W., Wu, Y. L., Cen, B., ... & Pei, G. (2000). β-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between β-arrestin and CXCR4[J]. Journal of Biological Chemistry, 275(4), 2479-2485.Jing, Q., Xin, S. M., Zhang, W. B., Wang, P., Qin, Y. W., & Pei, G. (2000). Lysophosphatidylcholine activates p38 and p42/44 mitogen-activated protein kinases in monocytic THP-1 cells, but only p38 activation is involved in its stimulated chemotaxis[J]. Circulation research, 87(1), 52-59.Zhao, J., Ben, L. H., Wu, Y. L., Hu, W., Ling, K., Xin, S. M., ... & Pei, G. (1999). Anti-HIV agent trichosanthin enhances the capabilities of chemokines to stimulate chemotaxis and G protein activation, and this is mediated through interaction of trichosanthin and chemokine receptors[J]. Journal of Experimental Medicine, 190(1), 101-112.Ling, K., Wang, P., Zhao, J., Wu, Y. L., Cheng, Z. J., Wu, G. X., ... & Pei, G. (1999). Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-transmembrane domain chemokine receptors[J]. Proceedings of the National Academy of Sciences, 96(14), 7922-7927.Jing, Q., Xin, S. M., Cheng, Z. J., Zhang, W. B., Zhang, R., Qin, Y. W., & Pei, G. (1999). Activation of p38 mitogen-activated protein kinase by oxidized LDL in vascular smooth muscle cells: mediation via pertussis toxin–sensitive G proteins and association with oxidized LDL-induced cytotoxicity[J]. Circulation research, 84(7), 831-839.科研成果奖励截至2009年2月，裴钢先后获得中华人民共和国教育部科学技术进步奖一等奖、国家自然科学二等奖、中华医学科技奖一等奖、上海市自然科学一等奖、上海市科技进步一等奖等 

时间项目名称奖励名称1998年孤啡肽受体及阿片受体的信号传导机理研究教育部科学技术进步奖一等奖2001年阿片受体磷酸化及其对受体信号转导的调控机制上海市科技进步一等奖2001年阿片类药物耐受和成瘾的分子机制研究中华医学科技奖一等奖（首届）2002年蛋白激酶在阿片类物质介导神经信号的转导和赖受依赖中的作用国家自然科学奖二等奖2006年G蛋白偶联受体信号与其它细胞信号通路间的对话机制上海市自然科学一等奖2007年G蛋白偶联受体信号与其它细胞信号通路间的对话机制国家自然科学二等奖2007年发现β抑制因子-11是调节CD4+T细胞存活和自身免疫性的关键因子中国基础研究十大新闻之一2011年上海市科技进步一等奖

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