孟安明科研成就科研综述孟安明早期从事水稻育种、畜禽DNA指纹图谱研究

1996年后，主要利用斑马鱼为模式系统，研究脊椎动物胚胎早期发育的分子调控机制，包括母源因子的作用、胚层诱导与分化的调控机制等，为理解和预防人类不育不孕和出生缺陷提供知识；发现多个介导中内胚层诱导及胚胎背腹分化的因子和新的作用机理

 项目承担第十一、第十二、第十三届全国政协委员 

据2019年3月中国共产党新闻网显示，孟安明主持“973”、国家重大科学研究计划、自然科学基金委等项目；提交提案建议10余项，多项被评为优秀提案

早期从事水稻育种、畜禽DNA指纹图谱研究

自1996年以来，主要利用斑马鱼为模式系统，研究脊椎动物胚胎早期发育的分子调控机制，包括母源因子的作用、胚层诱导与分化的调控机制等，为理解和预防人类不育不孕和出生缺陷提供知识 

学术论著据2019年3月中国共产党新闻网显示，孟安明发表SCI论文50余篇

代表性著作Meng, A., J. Jessen and S. Lin. 1999. Transgenesis. Methods in Cell Biology, 60: 133-148.代表性论文Zhao J, Cao Y, Zhao CT, Postlethwait J, Meng AM. 2003. An SP1-like transcription factor Spr2 acts downstream of Fgf signaling to mediate mesoderm induction. EMBO Journal, 22(22): 6078-6088.Zhao ZX, Cao Y, Li M and Meng A. 2001. Injection of double-stranded RNA produces nonspecific defects in zebrafish. Developmental Biology, 229(1):215-223.Meng A, Moore B, Tang H, Yuan BZ and Lin S. 1999. Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates. Development, 126:1259-1268.Meng A, Tang H, Yuan BZ, Ong BA, Long Q, Lin S. 1999. Positive and negative cis-acting elements are required for hematopoietic expression of zebrafish GATA-1. Blood, 93(2):500-508.Meng A, Tang H, Ong BA, Farrell MJ, Lin S. 1997. Promoter analysis in living zebrafish embryos identifies a cis-acting motif required for neuronal expression of GATA-2. Proc. Natl. Acad. Sci. USA, 94:6267-6272.Huang HZ, Lu FI, Jia SJ, Meng S, Cao Y, Wang YQ, Ma WP, Yin K, Wen ZL, Peng JR, Thisse C, Thisse B, Meng AM. 2007. Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation. Development, 134(5): 979-988.Xiong B, Rui YN, Zhang M, Shi KH, Jia SJ, Tian T, Yin K, Huang HZ, Lin SY, Zhao XG, Chen YH, Chen Y-G, Lin SC, Meng AM. 2006. Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal b-Catenin transcriptional activity. Developmental Cell, 11(2):225-238.Lin X, Duan XY, Liang Y-Y, Su Y, Wrighton KH, Long JY, Hu M, Davis CM, Wang JR, Brunicardi FCB, Shi YG, Chen Y-G, Meng AM, Feng X-H. 2006. PPM1A functions as a Smad phosphatase to terminate TGFb signaling. Cell, 125(5):915-928.Zhang LX, Zhou H, Su Y, Sun ZH, Zhang HW, Zhang L, Zhang Y, Ning YH, Chen YG, Meng AM. 2004. Zebrafish Dpr2 inhibits mesoderm induction by promoting lysosomal degradation of Nodal receptors. Science, 306(5693):114-117.Cao Y, Zhao J, Sun ZH, Postlethwait J, Meng AM. 2004. fgf17b, a novel member of Fgf family, helps patterning zebrafish embryos. Developmental Biology, 271(1):130-143.Zhao J, Cao Y, Zhao CT, Postlethwait J, Meng AM. 2003. An SP1-like transcription factor Spr2 acts downstream of Fgf signaling to mediate mesoderm induction. EMBO Journal, 22(22): 6078-6088.Zhao CT, Shi KH, Su Y, Liang LY, Yan Y, Postlethwait J, Meng AM. 2003. Two variants of zebrafish p100 are expressed during embryogenesis and regulated by nodal signaling. FEBS Letters, 543(1-3):190-195.Zhao ZX, Cao Y, Li M, Meng AM. 2001. Injection of double-stranded RNA produces nonspecific defects in zebrafish. Developmental Biology, 229(1):215-223.Meng AM, Moore B, Tang H, Yuan BZ, Lin S. 1999. Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates. Development, 126:1259-1268.Meng AM, Tang H, Yuan BZ, Ong BA, Long QM, Lin S. 1999. Positive and negative cis-acting elements are required for hematopoietic expression of zebrafish GATA-1. Blood, 93(2):500-508.Meng AM, Tang H, Ong BA, Farrell MJ, Lin S. 1997. Promoter analysis in living zebrafish embryos identifies a cis-acting motif required for neuronal expression of GATA-2. Proc. Natl. Acad. Sci. USA, 94:6267-6272.

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